Gestern bin ich ueber einige Artikel gestolpert, in den Viagra dafuer verwendet wird die GMSH aufzubauen und es wirkt wohl auch, um die NKs in der GM zu senken. 😮

Hier mal mehr Infos:

http://www.ejwm.org/search.php?where=aview&id=10.5468%2Fjwm.2010.3.4.155&code=0637JWM&vmode=FULL

Sildenafil was reported to augment baseline and estrogen-induced uterine blood flow in surgically menopausal ovine model. Sildenafil acts as a type 5-specific phosphodiesterase inhibitor hence augments the vasodilatory effects of nitric oxide by preventing the degradation of cGMP. In one observational study, administration of vaginal sildenafil for 5 weeks could improve endometrial thickness in women with a history of recurrent miscarriage.

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Aber dies gilt wohl nur fuer den Frischversuch, nicht bei Kryos. Da wurden 25mg (manche geben auch 100mg) pro Tag vaginal gegeben fuer 10 Tage in der 2. ZH ODER nur bis ES Ausloesen gegeben.

Die transferieren 5! Embryos! *ohnmacht*

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http://online.liebertpub.com/doi/abs/10.1089/jwh.2006.15.442

[…] It is suspected that this medication causes selective vasodilatation, resulting in improved endometrial development.

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Viagra hat gefaesserweiternde Wirkung und wirkt damit auch auf die GMSH.

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http://www.fertstert.org/article/S0015-0282%2808%2904783-3/abstract

Patient(s)

Sixty-one patients with a thin endometrium (endometrial thickness [EM] <8 mm) and high radial artery-resistance index of uRA (RA-RI ≥0.81).

Intervention(s)

Vitamin E (600 mg/day, n = 25), l-arginine (6 g/day, n = 9), or sildenafil citrate (100 mg/day, intravaginally, n = 12) was given.

Main Outcome Measure(s)

EM and RA-RI were assessed by transvaginal color-pulsed Doppler ultrasound.

Result(s)

Vitamin E improved RA-RI in 18 (72%) out of 25 patients and EM in 13 (52%) out of 25 patients. L-arginine improved RA-RI in eight (89%) out of nine patients and EM in six (67%) patients. Sildenafil citrate improved RA-RI and EM in 11 (92%) out of 12 patients. In the control group (n = 10), who received no medication to increase uRA-blood flow, only one (10%) patient improved in RA-RI and EM. The effect of vitamin E was histologically examined in the endometrium (n = 5). Vitamin E improved the glandular epithelial growth, development of blood vessels, and vascular endothelial growth factor protein expression in the endometrium.

Conclusion(s)

Vitamin E, l-arginine, or sildenafil citrate treatment improves RA-RI and EM and may be useful for the patients with a thin endometrium.

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Vit E, L-Arginin oder Viagra kann die GMSH verbessern. Vit E verbessert das Glandular GMSH Wachstum, Entwicklung der Blutgefaesse, und Endothelzellenwachstum.

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http://www.greenpharmacy.info/article.asp?issn=0973-8258;year=2012;volume=6;issue=2;spage=118;epage=129;aulast=Bhandari

Knoblauch ist pro-Inflammatorisch! (nicht nehmen, bei hyperaktivem Immunsystem)

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http://www.ingentaconnect.com/content/ben/cwhr/2010/00000006/00000003/art00003

pdf >> klick

PAI-1 ist ein Faktor fuers Endometrium? Oh… gut zu wissen, dass es auch daran liegen kann, dass die Schleimhaut schlecht waechst und es zu keiner Einnistung kommen kann.

The study found a link between one or more of the genes and patients with re- peat implantation failure. A significantly higher correlation existed for RIF patients than the control group. More studies are needed to confirm the findings, which could facilitate the clinician’s ability to identify and counsel patients prone to implantation failure

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Natural killer cell activity levels, which have been reported as a predictor for recurrent miscarriages, may also be involved in RIF. An increase in both peripheral blood natural killer cells and endometrial natural killer cells appears to be associated with lower pregnancy rates in patients with recurrent miscarriages. Upon activation with nitric oxide, the natural killer cells release cytokines such as tumor necrosis factor, which has been implicated as a cause of implantation failure. One study extended the hypothesis to suggest that repeated implantation failures may be caused by high levels of peripheral natural killer cell activities. It showed that sildenafil lowered peripheral blood natural killer cell activity, thereby improving the local endometrial immunological environment in women with multiple IVF failure. However, more randomized control studies must be done to confirm these findings. It also will be important to determine the appropriate period to prescribe sildenafil therapy.

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The Th1 cytokines include IL-2, IFN and TNF, and the Th2 cytokines include IL-4, IL-5 and IL-10. Evidence suggests that the mean of the Th1:Th2 ratio in patients with RPL and in patients with multiple implantation failure after IVF-embryo transfer [188] is significantly higher than in normal fertile women.

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IVIGs:

A more recent report suggests IVIg suppresses NK activity, specifically the CD56 bright subset of NK cells found at the feto-maternal surface. Additionally, one underlying mechanism may be the restoration of Th1/Th2 balance with dominant Th2. Highdose IVIgs nearly always have been combined with corticos- teroids or anti-thrombotics, so that their precise efficacy cannot be readily estimated and is practically hard to assess.

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http://www.klein-putz.net/forum/viewtopic.php?t=45176

Teilweise aus Dr Beer kopiert.

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http://www.fertilityfriends.co.uk/forum/index.php?topic=242395.10

Welche Tests notwendig sind. (Viel Zeit mitbringen, es ist sehr umfangreich!) Hier muss ich spaeter noch nachtragen! – kleine Schrift *Augen reib*

Vielleicht sollte ich doch nochmal Rheuma machen lassen und Lupus??? Evt auchs elbst bezahlen?? 😦

‚Generic‘ viagra is also available as a citrus flavoured oral jelly which some docs have suggested could be applied vaginally.

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Trental (Pentoxiphylline) is another drug with some vasodilation effects which has been used in studies but is less favoured by SIRM/Dr Sher.  In studies by other clinics it was used successfully at 400mg twice a day doses together with vitamin E (in a study with patients who had diagnosed thin lining and elevated NK cells. Trental is used by some immunology clinics particularly for endometriosis patients because of its immunosuppressive effects.

Vitamin E (600mg/day) and L arginine (6g/day) have also been shown to improve uterine artery bloodflow and endometrial thickness but seem to be less effective than viagra.  Vitamin E is available in supermarkets and health food shops.  L arginine is available in healthfood shops – please see the comments below under Supplements.

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Adequate protein and selenium intake is also important for lining growth, so some ladies take extra protein in the form of protein powder, chicken, eggs etc and selenium (see supplements) as a supplement or perhaps as extra pineapple or brazil nuts which tend to be fairly high in selenium content.

From a chinese medicine point of view, keeping your feet (and belly) warm is supposed to be essential for lining growth, so unless the weather is hot, it is suggested that you always wear socks and try to wear a long vest.

Caffeine is thought to reduce bloodflow to the lining – so its best avoided.

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http://humrep.oxfordjournals.org/content/15/4/806.full.pdf+html

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http://171.67.114.118/content/10/3/252.full.pdf+html

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http://www.sciencedirect.com/science/article/pii/S0015028207032931

Main Outcome Measure(s)

Peripheral blood NK-cell activity before and after vaginal sildenafil therapy in the RM women was measured using flow cytometry. In addition, the influence of 10 μg and 400 ng sildenafil on NK-cell activity after in vitro culture were determined. Uterine artery blood flow and endometrial thickness were recorded using Doppler ultrasound with an intravaginal probe.

Result(s)

The NK-cell activity was significantly decreased after vaginal sildenafil therapy. Endometrial thickness was significantly increased after such therapy.

Conclusion(s)

Vaginal sildenafil might be an interesting therapeutic option before conception in women with histories of reproductive failure.

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So NK Zellen runter und GMSH dicker!

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http://www.wunschkinder.net/infosammlung/Erweiterte

IVIGs:

  • direkte Unterdrückung der natürlichen Killerzellaktivität
  • positiver Einfluß auf die Balance von entzündungsfördernden Hormonen, die den Erfolg der embryonalen Einnistung / Frühschwangerschaft? maßgeblich kontrollieren
  • Anti-ideotypische Antikörper stellen sich dem ungünstigen Effekt von Autoimmunantikörpern entgegen
  • Deaktivierung von T- und B-Zellen, die möglicherweise eine Rolle spielen bei immunologischer Infertilität

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Trental:

  • Direkte Reduzierung von natürlicher Killerzellaktivität
  • Unterdrückung der Produktion von Entzündungsmarkern (TNF, IL-1 +2, Gamma Interferon)
  • Stimmulation von entzündungshemmden wirkenden Zytokinen (IL-6, IL-10)
  • Unterdrückung der T-Zell Aktivierung
  • Direkte Reduzierung der entzündlichen Aktivität von Makrophagen

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Trental hilft ‚gegen‘ Endometriose.

Viele Frauen mit Endo leiden zusätzlich noch daran, daß sie nicht besonders gut auf Stimmulationsmedikamente ansprechen. Die normale Patientin produziert etwa 10 -20 Eizellen unter der Stimmulationsbehandlung mit Gonadotropinen, die „poor responders“ (~ „schlechte/arme Reagierer“ auf Gonadotropine) haben vielleicht 1 -5 Eizellen.

Für dieses Problem gibt es eine Reihe von Gründen. Schwere Verwachsungen im Beckenbereich können zu einer schlechten Durchblutung der Eierstöcke führen und diese somit weniger gut auf injizierte Stimmulationsmedikamente reagieren lassen. Ähnliche Probleme werden aber auch bei Frauen beobachtet, die Ops hatten um Verwachsungen zu beseitigen.

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http://www.wunschkinder.net/forum/read/1/5097116 – KIR Thread

Viel Soja + Seefisch, wenig Milch.

Ganocyte:

– es verschiebt Th1:Th2 zu Th2
– indem es IFN-y – und IL-4 + macht
– es hilft bei der Ovulation
– ist ein pro Schwangerschaft und contra Endo Indikatior
– hemmt die NKs (den Link finde ich so schnell nicht mehr)

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http://humrep.oxfordjournals.org/content/24/8/2048.full?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=kir&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT

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http://haveababy.com/fertility-information/ivf-authority/uterine-receptivity-its-role-in-embryo/

Treatment with vaginal Viagra: Hitherto, attempts to augment endometrial growth in women with poor endometrial linings by bolstering circulating estrogen blood levels (through the administration of increased doses of fertility drugs, aspirin administration and by supplementary estrogen therapy) have yielded disappointing results.

We recently demonstrated that the vaginal administration of sildenafil (Viagra) for several days prior to the “hCG trigger “ or progesterone administration enhances uterine blood flow and estrogen delivery to the uterine lining, and so improves endometrial thickening.

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